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Found 19 results

  1. I wanted to alert anyone seeking a Baclofen prescribing doctor that I recently communicated with Dr. Philip E. Thomas in the UK who runs a Baclofen website where he states that he prescribes to his many hundreds of patients including patients in the USA. He contracted with me for his 12 week program. I sent him a wire transfer for $2000 USD for his "12 week program". He was friendly, concerned, responded to my emails until he received the money. I never heard from him again. He will not respond to my emails. My bank has confirmed with his bank that he received the money. My bank recalled the wire transfer but Dr. Thomas did not return the money. He provided no services for the money. I saw another posting by someone on another Baclofen forum that said Dr. Philip Thomas was a fraud, don't send him any money. This person said Dr. Thomas took his money and then could not be reached by email or phone. I have filed fraud charges against this doctor. Don't want anyone else to have this happen to them. Don't send Dr. Phillip E. Thomas in the UK any money. He uses many alias to post on Baclofen forums and is still active in his postings, pushing his prescribing handbook and more.
  2. Hey guys, I'm having a very hard time tapering down gabapentin (currently at 1200mg/day) while on high dose baclofen (140mg/day). Prior to my use of baclofen, I had been able to taper off of gabapentin with relatively little discomfort - some anxiety and insomnia for a few days after stopping, but it was manageable. This time around, however, I'm getting a large increase in anxiety every time that I try to reduce my dose for a stretch. Has anyone else had any success in tapering off of gabapentin while taking baclofen?
  3. Current high dose baclofen patient (140mg a day), who experienced great success (alcohol free, very little anxiety) for the first 7+ months, and then foolishly experimented with another GABAb agonist (phenibut) after losing a portion of my baclofen prescription. Though I was able to stop the other GABAb agonist by substituting it with baclofen, the dose I'd been at was no longer as effective. I titrated my baclofen use down to zero (with the aid of gabapentin to combat some of the anxiety I was experiencing), but only performed a baclofen drug holiday of 24 hours before resuming. In doing so, I increased my dose very rapidly, as I was not experiencing somnolence at doses of 80mg a day, and increased to 140 the next day. I am now suffering as baclofen is no longer as effective (battling extremely increased anxiety, vivid dreams and "electric shocks" in hands, but still alcohol free - in essence, it seems that I lost my "switch." My plan is to titrate my baclofen dose back down to zero to take more of an extended break, with the hope that resuming treatment will be effective after a hiatus. There are also a few supplements that I'm interested in exploring during my future break from baclofen, and I will share my results. Looking for support and information regarding others who have experienced tolerance issues with baclofen, and have perhaps found ways to overcome them. Currently experimenting, myself, and will be happy to share my findings/experience with the community. Much gratitude and warm wishes to all =)
  4. [Disclaimer: I have some background in pharmacology, but I am not a medical doctor.] Hey everyone! What follows is information regarding the mechanism of action of baclofen as well as similar substances, their effect on anxiety, and my thoughts/implications. [I've decided to add elements of my personal story and current situation in the hopes that others can learn from my insights as well as my mistakes.] Baclofen's mechanism of action involves agonism of the GABAb receptor, as well as slight inhibition/attenuation of voltage-dependent calcium channels (VDCC). Some studies suggest that it is the agonism of the GABAb receptor that causes the attenuation of the VDCC as a downstream effect, but further research is required. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230969/) It is this combined action that is the mechanism by which baclofen's effects (lack of interest in drinking, reduction of anxiety) is achieved. How so? Well, it is well known that one of the mechanisms of alcohol's temporary reduction in anxiety is due to its agonism of the GABAa receptor. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574824/) Another study has shown that application of a GABAb antagonist (the opposite of an agonist) increased the GABAa's sensitivity to alcohol. (http://jpet.aspetjournals.org/content/312/3/1082) So, while this is some deductive reasoning on my part, it seems to stand to reason that one effect of a GABAb agonist such as baclofen is that it might decrease the pleasure/effectiveness of alcohol by decreasing the sensitivity of the GABAa receptor to its effects. Furthermore, it has been shown that GABAb agonism has positive effects in the mediation of depression and anxiety. (https://www.ncbi.nlm.nih.gov/pubmed/18195453) I believe that it is by these mechanisms - reduction of sensitivity of the GABAa receptor to ethanol's effects (speculative, but this could contribute to the "switch" that many who keep drinking up to a point report), and the positive effects GABAb agonism has on anxiety and depression (fact!), that many lose interest in drinking following the administration of high dose baclofen. As I stated, however, another one of baclofen's effects is its attenuation of voltage-dependent calcium channels (VDCC). VDCC attenuation has also been implicated in the reduction of anxiety. This has been shown by studies on lavender (product such as Calm Aid/Silexan, for example: https://www.ncbi.nlm.nih.gov/pubmed/29073181), as well as Neurontin (gabapentin), a well known medication that is prescribed off-label for anxiety that's primary mechanism of action is thought to be its attenuation of VDCC (with some kind of relation to GABAb, no less). (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176314/). And so, there is strong evidence to suggest that GABAb agonism as well as attenuation of VDCC is what accounts for baclofen's effects. Another substance that has similar effects to baclofen is phenibut. Like baclofen, phenibut also selectively agonizes the GABAb receptor and attenuates the VDCC, but with reverse strength: baclofen is a stronger agonist of the GABAb receptor than phenibut, but phenibut attenuates the VDCC more strongly than baclofen. The actions of phenibut (r-phenibut, in the study), baclofen, and gabapentin in terms of their binding affinity/activity at the GABAb and VDCC were measured in this study: shttp://www.sciencedirect.com/science/article/pii/S009130571530037X Below is a table from that study that represents their findings: The measures of the binding affinity at the α2–δ subunit of voltage-dependent calcium channels are shown in comparison to GBP (gabapentin), as gabapentin exerted the strongest effects there of the substances tested (in this case the lower the number, the stronger the binding affinity, and the inverse relation of binding affinity of phenibut and baclofen at the VDCC and GABAb receptor are evident). Now, that is the groundwork from which I will now make some claims, as well as tell a little bit of my personal story. The first is that "anxiety," writ large, originates within the brain. The specific neurological/psychological underpinnings that "cause" anxiety, or make some more anxious in some situations, or experience different kinds of anxiety, involve a complex picture of an individual's brain, genetics, experiences, psychology, substances/medications taken, and the interplay between. For some of us who grew up and experienced social anxiety in certain contexts, alcohol provided the right kind of relief in those situations - I fall into that category. For me personally, years of achieving relief in social situations gradually (over years) spilled into me drinking more and more, and I became an alcoholic. I actually experienced a period of time whereby I stopped drinking for about 2.5 years, and suffered from terrible post-acute withdrawal syndrome (PAWS). Why was this? Although this is something of an oversimplification (and going back to how everything stems from the brain), evidence suggests that a big part was that my years of alcoholism had down regulated my GABAa receptors (the same ones that benzodiazepines attach to/agonize), making them less able to provide an effective inhibitory response to stress/anxiety on their own (without the presence of alcohol/other GABAa agonists). (https://www.ncbi.nlm.nih.gov/books/NBK98172/) In my case, towards the end of my second year of abstinence, things actually did begin to improve at a fairly consistent and noticeable rate. I began to feel like my old self, in a sense, and could handle social situations/life in general far better than I had in the earlier stages of recovery. Unfortunately, however, that eventually lead to me thinking that I could try my hand at drinking again, and disaster and alcoholic patterns began to resurface full force about a year into my reintroduction. Eventually, after many attempts to stop (and during an abstinent period) I found baclofen approximately 8 months ago, and my life improved dramatically, with all of the benefits users report throughout this forum and beyond. Throughout my use of baclofen, I noticed a few interesting things after taking other substances. The first deals with benzodiazepines. There were a couple occasions in which I took small doses of benzodiazepines during my baclofen treatment with very little negative effect. However, there was one occasion in which I took multiple doses for a short time (I believe a day and a half, perhaps two days at most), and experienced very noticeable rebound anxiety for a period of about 4-5 days after. During that time, I had attempted to increase my baclofen dosage (my usual dose is 140mg/day) in order to offset that anxiety to no avail. I believe that the explanation for this is simple: benzodiazepines agonize GABAa receptors, while baclofen agonizes GABAb. The anxiety that I was experiencing was due to the lack of agonism at a receptor that baclofen simply doesn't hit, and thereby had little effect in mitigating. I bring up this example to again suggest that not all "anxiety" is the same, PARTICULARLY when it results from the use of other substances/medications. I also think this is why some of us who have used benzodiazepines extensively in the past fail to receive as much of an anxiolytic effect from baclofen - it is simply a different receptor, and the GABAa receptor must have time to upregulate on its own (away from any GABAa agonists) before anxiety stemming from that source will dissipate. This next bit of my story is admittedly uncomfortable for me to express because it describes a situation that I am currently dealing with, and it brings me a great deal of distress. My hope, however, is that it helps anyone else from falling in to what has happened to me, or helps to provide some insight into what others (anyone now or in the future) might experience. Awhile back I lost a portion of my baclofen prescription, and after some research on the internet (at this time, I was still unaware of how more baclofen could be procured through online pharmacies/sympathetic and wonderful souls on forums), found that phenibut would seemingly be able to serve much of the same purpose of baclofen given their incredibly similar molecular structure and mechanisms of action. I was, however, unaware of a key and aforementioned difference between them: while both agonize the GABAb receptor, phenibut also attenuates the VDCC much more strongly than baclofen. After a period in which I was combining a lower dose of baclofen (40mg-60mg) with phenibut to great success, I decided that enough was enough after I was able to get a refill of baclofen. The transition from lower dose baclofen with phenibut to my regular dose of baclofen, however, was crushing, as I was overwhelmed with intense anxiety that even higher doses of baclofen were unable to address. More internet research allowed me to find that many users of phenibut had successfully combat the anxiety of withdrawals with gabapentin, and I indeed felt immediate relief upon taking some that I'd had on hand from a leftover prescription. What I now know, but was unaware of at the time, is that my anxiety was due to my brain having grown accustomed to the level of VDCC attenuation provided by phenibut. When that was removed, massive, crippling anxiety followed until I was able to attenuate the VDCC yet again with gabapentin (making up for the difference in attenuation that baclofen lacked). However, I am now in a seemingly very dire situation. I recently began to try stopping gabapentin altogether, and moved from a dose of 1800mg/day (relatively high, that I'd been on for six weeks) to 900mg/day. In fact, the day after, I tried to eliminate gabapentin completely. Obviously, this was silly on my part, but I had no idea of what was to come. After experiencing rising anxiety in the days following my discontinuation, I eventually experienced the onset of delirium (visual signs, similar to what I had experienced during alcohol withdrawal) on the third night. Gabapentin withdrawal induced delirium has been recorded in medical literature (a meta-analysis with PubMed ID numbers of other cases can be found here: http://journal.pulmccm.org/article/gabapentin-withdrawal-causing-adrenergic-toxidrome/). I immediately took another 300mg dose of gabapentin, fell into fractured (a couple hours at a time) sleep, and when I awoke took another 300mg dose of gabapentin. As it began to take effect, I experienced growing numbness along the right hand side of my body, literally in real time. In the days that followed, I (perhaps foolishly) enacted a start-stop relationship with gabapentin, thinking that I could just take an ever smaller dose every third day or so to prevent the onset of delirium. I never made it that far as the anxiety rising within me between each dose was simply too great. I began taking gabapentin again at a dose of 300mg twice daily, and am now in the process of tapering down (currently at 200mg twice daily). However, with each successive dose of gabapentin, I am experiencing more and more symptoms of neuropathy/numbness in areas throughout my body, as well as deterioration of vision and increased tinnitus. I am not entirely sure by what mechanism this is happening, but as gabapentin's primary indication is for the treatment of neuropathic pain, I can only assume that I am experiencing these effects as a result of its actions (attenuation of the VDCC) in combination with high dose baclofen. Now, I am aware that I have a unique history, had been using a relatively high dose of gabapentin in combination with my usual 140mg/day of baclofen, and did not initially think to taper it down in a conscientious or safe manner. I am by no means trying to insinuate that it is dangerous to use gabapentin in combination with baclofen, but I feel it necessary to share my experience in the possibility that there is a yet unstudied/unknown danger, perhaps at higher doses and for longer periods of time. At the very least, it stands to reason that one who is using gabapentin in combination with baclofen for an extended period might suffer from some anxiety after stopping gabapentin, similar to how some users of gabapentin report withdrawal/increased anxiety upon stopping (and because baclofen alone will not account for the increased attenuation of the VDCC that gabapentin provides). In the study I linked up above (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176314/), the authors write that "It is concluded that GBP selectively activates presynaptic GABAB heteroreceptors, but not GABAB autoreceptors." It is above my pay grade to know exactly what that means, but it does certainly suggest that gabapentin has some activity with some GABAb receptors. In fact, another study found that gabapentin does potentiate (increase) some of the effects of baclofen by some mechanism: https://www.ncbi.nlm.nih.gov/pubmed/14704478. So, there is clearly some level of interaction between the two. I am worried that perhaps my use of high dose baclofen along with relatively high dose gabapentin (honestly, probably higher than I needed to simply combat the phenibut withdrawal) perhaps elevated the effects of the "dose" of baclofen I've been taking to something akin to higher than 140mg, and I am now in some state of constant, sub-acute withdrawal that is causing CNS dysfunction (and could also account for the onset of my delirium being more akin to baclofen withdrawal, rather than gabapentin withdrawal). This is pure speculation, but I thought I'd share it, nonetheless. And so, my current game plan is to continue to take 400mg/day in divided doses today and tomorrow, and then drop down to perhaps 100mg TID for a period of a few days before tapering back down to zero, and hoping as much as possible that (a) the CNS symptoms I'm experiencing progress at a slow enough rate that they are "tolerable," despite how ridiculously scary this entire enterprise is, and (b) that I do not begin to experience delirium again after stopping completely. If I do indeed begin to experience delirium again, I fear I will have no choice but to take gabapentin again, and then resort to potentially dangerous and blind measures, such as trying to stop gabapentin again while increasing my dose of baclofen to something higher than 140mg. I should say that there was a day (without the use of gabapentin) that I was able to increase from 140mg to 240mg, the only side effects being incredibly vivid dreams [Side note: A study here https://www.ncbi.nlm.nih.gov/pubmed/28347366 concluded that "in the absence of norepinephrine activity (as in REM sleep), cholinergic activity is unable to yield long-term synaptic changes, such as those implicated in memory retention, which would partly explain the well-known difficulty of recalling oneiric activity." Another study found that baclofen increases norepinephrine turnover (https://www.ncbi.nlm.nih.gov/pubmed/2873522), essentially the amount of its activity in the brain, which seems to explain why many people report vivid dreams that they remember at higher doses of baclofen ]. And so, if the onset of my delirium was in fact due to gabapentin having made my brain accustomed to a "higher" dose of baclofen by potentiating my regular dose, perhaps increasing baclofen alone will account for that deficit, and I will then be able to titrate down. This is of course incredibly scary, as I simply DO NOT KNOW exactly why I am experiencing all of these symptoms, and will not know more until I basically continue to run this crazy and frightening experiment on myself. My first course of action is to continue with what I am doing, CNS dysfunction notwithstanding, to see if tapering down my gabapentin at this rate allows me to stop it entirely without the onset of delirium. One absolute moral of the story is to never use phenibut if already taking baclofen - @Jetsman32, I understand you were using phenibut prior to your use of baclofen, so I suspect that you'd be in nothing like the same boat as me, though I'm wondering if perhaps you found that baclofen did not do as much to alleviate your anxiety as you had hoped? Though gabapentin might theoretically offer some reprieve in that regard, I'd humbly warn against being inclined to take high doses of it for long periods of time until more is known about the interplay between it and baclofen, and to TAPER down if you elect to use it. Again, this is all PURE theoretical reasoning, and so I AM NOT trying to tell anyone what to do or to raise any kind of undue alarm. As for my situation, I will report back here when I can, and am happy to answer any questions for as long as I can. Though I am absolutely scared of what fate will befall me (that I've brought upon myself), I am not depressed, just merely disappointed. I love life, and all that there is to it. I wish all of you all the best, and truly hope that no situation such as mine is ever experienced by anyone, ever. Warmly, TR P.S. On another, unrelated note, I am incredibly interested in finding accounts of people who have successfully tapered off of high dose baclofen completely after being on it for a stretch. I'd like to know what the experience of life was like after coming off of it completely, namely as to whether there were any symptoms of discontinuation (anxiety, mood changes, etc.). This is because I am wondering if, like benzodiazepines, there would be any symptoms of post-acute withdrawal due to GABAb downregulation after coming off of a high dose of a GABAb agonist like baclofen for some time. I also wonder whether GABAb downregulation accounts for why many who titrate down need to go up higher to (or possibly don't ever) find their "switch" (thanks, @Baclofenman). The only other GABAb agonist that I can find that some people have taken regularly for long periods is GBL/GHB, however I am unable to find any accounts online of anyone actually stopping and recovering after long periods of use. In any case, that is a discussion/topic for another time, as at present, I obviously have far bigger things to deal with. Also, thanks to @Felina, @Molly78, and again @Baclofenman for getting back to me when I initially posted an albeit incomplete introduction, and before I realized just how serious of a situation I was in. ------------------------- @Admin1, @Admin2 @baclofenresearch - I just want to bring this post to your attention, as it includes much research as well as my personal plight.
  5. empyr3al

    Baclofen withdrawl

    I titrated baclofen up to 30 mg but experienced a loss of personality. Things seemed to just be matter of fact. Gaba B was not something I should have messed with recklessly when i was perfectly fine. I'm 6 months sober. I could see it making sense if you were coming off alcohol but being sober long enough it appears quite different. I question at what cost to self realization is using a drug so intense that coming off of it is almost like coming off alcohol. Diazepam is the only thing making me stable at the moment. Has anyone else tried using Bac while totally sober and what did it feel like.
  6. Jetsman32

    First day on Baclofen

    Hi All, Hope everyone is doing well. Yesterday my order of Baclofen finally came in the mail! I was so excited to get it and decided to start it today. So, I've now been clear of alcohol for 9 days straight - which I'm pretty proud of. Anyway, during this time I've still been dosing phenibut daily- usually around 3-4 grams to maintain my sanity (this is a fairly high dose). On top of that I take a ton of herbs like passion flower, l-theanine and Valerian. I also use aniracetam- a nootropic for mood improvement and klonopin (although I've hardly touched it over the last week). I read a lot of places that phenibut and baclofen have a very similar chemical composition but didn't want to risk having them on the same day (couldn't find any info on the web about combining the two)- that is why I waited until today to start. I was really scared of a bad reaction. So instead, I stopped phenibut cold turkey and started today on the baclofen. I'm starting my dosage at 30mg per day (10mg X3 times per day). I know it is recommended to start a bit slower but I did some research and figured that the phenibut tolerance I've built up would make it necessary to avoid some really bad withdrawal symptoms associated with Phenibut. So far I've dosed twice today. Initial side effects are mild naseau and some slight tingling in my left arm. Other than that it's been fine. I should also add that I was prescribed a 6 day treatment of prednisone (oral steroid) for my back which I started today as well so the side effects could be coming from that. I've still been using my other stuff today. Had 2 servings of aniracetam and l-theanine but have still avoided the klonopin. My anxiety is definitely there today- i can tell i'm not on phenibut for sure but it is almost manageable. Anyway, I took my first 10mg this morning at 7am, my second at 1:00pm and will take my 3rd at 7:00pm. In reading through these pages I saw that peeing the bed is a possible side effect as well as bad dreams so I'm making sure my final dose is well before bed (11:00pm). Anyone else had these side effects? My one huge fear is that I'm not going to be able to sleep tonight. Phenibut has a really long half life and allowed me to get to bed and fall asleep quickly. I'm worried the withdrawals are going to have me up all night once the last dose of baclofen wears off. I stopped and picked up some melatonin though and if it comes to it, I will take the Klonopin just to get some rest (I fly out to Boston tomorrow for a business trip). My plan is to still titrate slowly. I will use 30mg for 3 days then move up to 40mg for 3 days and so on. I've even created a dosage calendar for myself so I can hold myself accountable. I've also met some awesome people on here that have been very supportive so I think this plan will work. Three big questions 1) Does that sound like a good plan- if not- be honest! 2) Any suggestions for withdrawals and getting to bed? 3) Am I mixing any herbs with baclofen that could lead to a bad reaction? Really hoping the baclofen works for me. Thanks everyone!
  7. EraserHead

    Weird BAC side effect

    Hi there, I'm on Day 85 of a baclofen regimen, and experiencing a weird side effect that I'm wondering if anyone else has experienced. Basically, a few hours after the third dose -- this would usually mean late in the evening -- I start hearing/feeling a "whooshing" sound inside my head, as if I was feeling blood rushing through veins or something. It occurs a couple inches behind the temples, simultaneously on both sides. It usually only occurs occasionally, but last night as I was trying to go to sleep it started occurring every 3 seconds; not frequently enough to coincide with my heart rate. I started to get worried, but then realized that my worry might be exacerbating it... I got out of bed, sat on the sofa and turned on the light, and was able to use some focused breathing techniques to make it go away after 10 minutes or so. Anyhow, has anyone on BAC ever experienced this?? Thanks! EH
  8. Hi All, Not sure if this topic is worthy of a new thread but I thought I'd give it a shot. As most of you know I hit indifference at 310mgs of Baclofen per day. I generally have no urge to drink and when I do drink I can do so reasonably and stop whenever I want. These are SUPER POWERS that others have and I could never grasp. I'm starting this thread because I've noticed that Baclofen has also affected other addictions in my life and I wanted to see if anyone else noticed this as well. Prior to becoming indifferent I was a huge PS4 gamer. I never played online because I hated talking to people so I would play role playing games like The Witcher 3, Mass Effect and Grand Theft Auto. I played these games for the story and the thrill of getting the next best piece of equipment or reaching the next cut-scene to see where the story was going. I would say that I played roughly 20 hours per week. My wife would go to bed at 10pm and I would play until 1 or 2am during the week. On the weekends I would lock myself in my man cave and sometimes stay up all night. I was truly addicted. Since become indifferent to alcohol this has gone completely away. I no longer feel and "need" to play video games. Some really great games have been released over the last four months and I just have zero interest in playing them. I've actually tried to play them but I only get about 30 minutes in and I get totally bored. Also prior to Baclofen I loved to binge watch television series on Netflix with my wife. We would watch 2-3 episodes of a show a night until we finished an entire season. If I remember correctly we watched all 7 seasons of Lost in about a month. It was insane! Since becoming indifferent I really have no interest in binge watching at all. My wife have started 2 or 3 series and we get bored after the 2nd or 3rd episode. Don't get me wrong, we still watch TV together when the kids go to bed but I find us switching shows every night and watching things that I've never even had interest in like documentaries and and true crime shows. Honestly I don't know if Baclofen had anything to do with these changes but I do know these changes happened as I titrated up on Baclofen. Has anyone else noticed changes like this or other addictions in your life go away through Baclofen? I'm starting to believe that Baclofen can be used for any number of disorders across the medical spectrum. Hell I don't know, maybe I'm reading to much into this but I would love your thoughts.
  9. JMS1776

    New to this forum and Baclofen

    Hello, I just joined this forum and thought I would introduce myself. I am in my mid 50's and live in California and have been trying to get sober since 2010. Alcohol is my drug of choice and it has caused a lot of problems in my life, primarily personal with my family and friends. I've been through two outpatient programs, countless AA meetings, SMART recovery, and counseling and nothing seems to blunt the cravings. I have tried Topomax, Naltrexone (both normally and through the Sinclair Method), and Campral. None of those had any sustained effect, although I did reduce my intake through the Sinclair Method. The longest sustained period of sobriety that I have managed is 7 months and that was in 2010. I'm an early riser and the first cravings hit in the morning (8:00 am) and grow in number and intensity as the day goes on. They reach a crescendo in the late afternoon (5:00 pm) and subside in the mid evening around 7:00 or 8:00 pm (whether I drink or not). Eating dinner always helps and idle time is never a good thing. My wife and I are empty nesters and I have a fair amount of free time on my hands, which I try to fill but am not always successful. I typically drink 1 pint of vodka in a concentrated period of time in the mid afternoon and then am done for the day. This is not to say that I don't on occasion drink more, but that is my typical pattern. My health is beginning to suffer as a result and I am just sick and tired of this. I and my family deserve better than this. But that voice in my head never takes a day off, ever.... I read Dr. Amiesen's book about 6 weeks ago. Naturally the notion of craving reduction/suppression intrigued me, so I decided to investigate further. I did some research and decided to go see my GP. He was supportive and willing to prescribe Baclofen off-label up to 40 mg initially. I went to see him a second time and he was willing to go higher based on some data that I provided to him. I started the medication on 8/16 at 10 mg and increased the dosage up to 110 mg by 9/2. From the beginning I was having side effects, the most noticeable of which are shortness of breath, nasal congestion, tightness in my throat and chest, tingling in my hands (although I had this prior to starting Baclofen), grogginess, increased muscle tension, sometime feeling of shocks, inability to concentrate, and generally feeling like shit. Rather than relaxing me, Baclofen seems to have the opposite effect. It should be noted that being the good drunk that I am I kept drinking during the first two and a half weeks and over last weekend the side effects started to intensify. I am very physically active and have continued to exercise every day despite these physical issues. On the plus side I have noticed that the cravings are reduced and easier to deal with. As a result I have been sober for all of 4 days now. I have also reduced my Baclofen intake to 60 mg per day. My hope is that these issues are going to reduce and eventually taper off. I am noticing that I am gradually feeling better, but many of the side effects are persisting. If anyone has any guidance on these issues I would appreciate the feedback. None of these feel life threatening and are in some ways similar to being hung over, which is a state that I am sadly well accustomed to feeling. Hopefully I can become one of the success stories here one day and return the favor. Thanks for reading.
  10. I'm on a lot of medication for my alcohol use disorder and major depression disorder /w concomitant anxiety. ALCOHOLISM: Acamprosate [Campral] 333mg TT (666mg) TID CF Baclofen [Lioresal] 20mg TID Topiramate [Topamax] 50mg BID DEPRESSION: Sertraline [Zoloft] 100mg TT (200mg) QD Aplenzin 348mg (bupropion [Wellbutrin] hbr) QAM Aripiprazole [Abilify] 20mg QD ANXIOLYSIS: Propranolol [Inderal] 60mg TID Amitriptyline [Elavil] 50mg QHS --- I stumbled upon a 750ml (fifth) of vodka I hid from myself three days ago; I am now thinking that drinking is gross! (after I ended up drinking it all at once, after a month clean.) I was not drunk at all. No euphoria whatsoever. I began to question what I ever found to be so elusive about drinking— I've been having cravings on the medication, tbh, but this slip up has actually made the cravings a lot better since I now know I won't enjoy the drink unless I stop taking the meds. I woke up the next morning with a mild hangover feeling too, and that is unusual for me. I'm becoming... indifferent to alcohol, but I still think about other drugs from time to time, but ETOH almost killed me. My anxiety is still high, and my depression is still there, but I think that symptomology will improve if I can stay sober. Is there a particular medicine I take that makes me adverse to the alcohol or maybe it's the combo of everything? Placebo? Thanks!
  11. I'm finally pulling my baclofen journey onto this site. It's over 3 1/2 years since I started on bac. It's been 10 months since I quit baclofen because of the SEs I had when I exercised in heat (tunnel vision, horrible fatigue, electrical shocks and an inability to hold onto things with my hands). I am so happy that I treated my alcoholism with baclofen. 2/7/13 I'm in my 6th week of baclofen for over drinking. My dr has stopped me at 60 mg/day. I have sent an email to him asking if he'll allow me to increase to follow Dr A's protocol. I have had a drink here and not so much there and I can truly say I have no craving or desire to drink. Yay! My first month on baclofen was so lovely. I sat in the sun and watched hawks and was enthralled with the world. Insights just flowed into my mind. Have others had this experience? In month 2 this all went away and my compulsive thoughts have returned. Could this be because I have quit increasing my dose? 2/8/13 Thanks everyone for your welcome! My dr has allowed me to go up to 80 mgs in the next week and a half. I'm off work for 3 days so I'll go to 70 today. xxxxx, you pose a wonderful question. I've thought for about 5 hours--do I want ease or to be alcohol free? My reason for starting baclofen was that I drank a bottle of wine a night and ruined love relationships (imagine that!!). Since my first week on baclofen I've not craved alcohol until this week when I started thinking about using it to escape how I felt. Maybe my lovely first month experience lulled me. Plus I'm in kind of a lull and I don't like them. I used to always whip something exciting up to get out of them. Maybe I'm being a baby and just wanting something easy. Prior to baclofen I was so tough and out of touch was any gentle feelings I had. It's tough for me when shitty memories come up. Whatever it is I'm not giving up. I've got my big girl panties on! I have read a ton about baclofen but it wasn't until this week that I found a few blogs. Again thank you to all of you for responding. 4/30/13 I have a couple of questions. I flipped my switch at 80 mgs after staying there for 6 weeks (My dr wouldn't let me go higher.). I titrated down slowly to 40 mgs and still had no desire for alc. Plus I lost that horrible lack of motivation I had at 80 mgs. I started getting anxious in the mornings and started taking 40 mgs in the morning and 10-20 mgs at night. So, now I can't sleep on my back or I snore myself awake. I have that wicked fatigue in late afternoon. This past weekend I bought my first lawn mower and I was so excited that I foolishly mowed my lawn in the middle of the day in the FL heat. I took plenty of breaks and drank tons of water. My lawn is a lot of sand and it was tough to get the front done. Then I got those electrical shocks in my hands and found it difficult to grip or hold things. Also I've started getting cramps in my legs and toes. I work in natural medicine so I use potassium, calcium magnesium and excellent quality vitamins. I'm fit although I haven't done much since starting bac in Dec. Prior to bac I hiked 10-12 mile hikes in the Everglades, and I want to continue. I know there's no rhyme or reason to SEs, but I'd like to know it does get better. 5/4/13 Thanks xxx, Yes, it's a pretty cool feeling. I used to get other sorts of things done, but it was always in an adrenaline fueled frenzy. It's nice to methodically do it and I have more $$ since I don't drink like a fool. I agree that the fear of doing it is the worst part. The next time I go to Miami I'm thinking of taking a trapeze class just to get past some more fear. bleep, I keep meaning to tell you that I'm going to show my son how to navigate the lawn mower on our sandy lawn and I won't mow it anymore. Plus I have held at a steady dose and taking the first dose a little later. So far so good. Thanks.
  12. Is there a rule of thumb for a maintenance dose of Baclofen? I thought I saw something about it being a percentage of your switch dose but I can't remember the percentage. 33% to 50% maybe? Or do you just titrate down until you get cravings and then bump back up some?. If anyone speaks French, can we ask this on their forum?
  13. Sam808

    Baclofen PDF Resources?

    This forum title is a little misleading. I was hoping to find the PDF of the book "The End of My Addiction" by Dr Olivier Ameisen. I tried buying the Kindle version on Amazon, but for some reason it's only available in the UK. The US Amazon site only has the paperback version, not sure why... So I did a lot of googling for the ebook version, but beware because there are many scam sites in the google results for this book! Don't click on the weird or uncommon looking domain names, they could lead somewhere ungood. My contribution to this forum is an excellent summary of the book I found from a neurology journal. The summary was written by a surgeon who describes his own first-hand experience with alcohol addiction and his success with Dr. Ameisen's book. http://onlinelibrary.wiley.com/doi/10.1002/pnp.226/pdf Hope this helps someone!
  14. Here is Dr. Stafford's Baclofen Treatment for Alcoholism website for those who may have missed it. I just sent it to my doc. Although she's already a Baclofen believer, I thought she would be interested in the section for physicians interested in prescribing Baclofen. Dr. Stafford references EOMA under resources/useful links http://baclofentreatment.com/ Mom2
  15. Baclofenman

    Baclofen Sales Chart

    Baclofen sales to the end of 2014
  16. Let's show her site some love! Check out the Baclofen News, where you can "like" the info. It's very exciting stuff. http://baclofentreatment.com/category/baclofen-news/ If you don't feel like clicking through and showing her we appreciate her work (I hope you will...but anyway...) There's a doctor in Perth who is now prescribing and I'll update the Doctor's Info with his name. But even more exciting is this: Berlin. 3rd September 2016. 4.30pm. The results of three big European baclofen studies will be announced in one session of the World Congress for Alcohol and Alcoholism (isbra-esbra-2016.org/welcome-3/). Baclofen treating doctors have been waiting a couple of years for this. These studies should put an end to the criticism that there is not enough evidence from large clinical trials to support the use of baclofen for alcohol use disorders. Can't wait for that conference!
  17. Determinator

    Det the newbie

    heya cats and kitties. New on this forum and new with baclofen. Out of frustration/desperation I managed to get Bac from my Doc just yesterday. I'd love to quit drinking immediately but a history of nasty withdrawal has me worried, so I'm trying to taper down once again. My current dosage is 10mg 3X per day. I realize I'll need to increase this tremendously to achieve success. thank you all for your support and what you do here. Especcially Neva. thank you dear.
  18. TimberTim

    Baclofen Side Effects

    I'm on a lower dose of baclofen; about 80mg/day. I know there is a whole list of side effects (SE's) that we all experience. I just wanted to talk about one and see if anyone else has it. Cold nose! I swear, now I know what my dogs go through! My nose is not wet, mind you. But when I go to bed or try to take a nap, I have to cover my nose because it feels like I have frost bite! Anyone else experience this?
  19. This is an extremely comprehensive look at the definition, causes, treatment and gaps in treatment of addiction. You can download the entire PDF from the link below. "The time has come for addiction medicine to be fully integrated into health care systems and medical practice. Health care providers, especially physicians, are our front line in disease prevention and treatment. They must understand the risk factors for addiction, screen for risky substance use and intervene when needed, and diagnose, treat and manage addiction just as they do all other diseases." http://www.centeronaddiction.org/addiction-research/reports/addiction-medicine
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