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Hello, Thank you for the forum. I hope I will find the information and help that I need here. I have been using TSM for a week now. I take 50mg 1 hr before drinking, poured a glass of wine and immediately feel the warmth and good feeling that makes me want to pour another glass... and another... by the end of the evening the bottle of wine is gone and I'm debating opening another. This happens to me every time I take Naltrexone (and when I don't). The medicine has had zero effect on the endorphines I receive from drinking. Has anyone else experienced this? By all accounts people say it curbs their drinking, but I honestly feel no difference. Any suggestions? I was really hoping that this would help me. Other attemps to stop or curb drinking have failed. Anyhow, thank you for listening and hopefully responding. I look forward to learning from all of you.