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Campral (acamprosate)

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Campral is one of three medications that is approved for the treatment of alcohol use disorders in the United States, Canada and Europe, and is used throughout the world. It has been researched for more than 30 years. 

There is more research supporting the safety and efficacy of campral than any other medication for AUDs. 

"Clinical efficacy of acamprosate [campral] is robustly documented in meta-analyses of available studies...the latter of these was a meta-analysis of 17 studies which included 4087 individuals."

Campral "had significant beneficial effect across 4 efficacy standpoints--percentage of abstinent days, percentage of no heavy drinking days, rate of complete abstinence and rate of no heavy drinking. Acamprosate [campral] had a high rate of treatment completion and medication compliance."2

"Acamprosate [campral] nearly doubled the likelihood of preventing relapse to drinking and increased the likelihood that patients would remain in treatment by nearly one third"3

"Acamprosate [campral] is more effective than naltrexone in maintining abstinence, while naltresone reduces heavy drinking and craving to a greater extent than acaprosate...Depending on patient geno-type, acamprosat and naltrexone have been shown to outperform one another."4

  • It has no serious side effects
  • It has no potential for abuse or rebound after discontinuation
  • It effectively reduces craving and can help people maintain abstinence
  • Like some of the other medications for AUDs, it is mot effective in people with a specific genetic marker--genetic variant GATA4. 

This information has been taken from the book A Prescription for Alcoholics - Medications for Alcoholism by Linda Burlison, Kindle Locations 5278-5817 and pages 275-297 in the book. A much more comprehensive understanding can be found there. It can be purchased at: http://www.amazon.com/gp/product/B01A1E8YKW?keywords=a%20prescription%20for%20alcoholics&qid=1458427110&ref_=sr_1_1&sr=8-1

Website: http://www.aprescriptionforalcoholics.com/

1. Heilig M, Egli M. Pharmacological treatment of alcohol dependence: Target symptoms and target mechanisms. Pharmacological Ther. 2006; 111(3):855-876. doi:10/1016/j.pharmthera.2006.02.01

2. Mason BJ, Lehert P. Acamprosate for Alcohol Dependence: A Sex-Specific Meta-Analysis Based on Individual Patient Data. Alcohol Clin Exp Res. 2012; 36(3):497-508. doi:10.1111/j.1530-0277.2011.01616.x.

3. Soyka M, Kranzler HR, Berglund M, et al. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: Alcoholism. worldJ Biol psychiatry. 2008; 9(1):6-23. doi:10.1080/15622970801896390

4. Yahn SL, Watterson LR, Olive MF. Safety and efficacy of acamprosate for the treatment of alcohol dependence. Sust buse. 2013; 6:1-12. doi:10.4137/SART.S9345.

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