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Selincro (nalmefene)

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Admin2

Nalmefene is an opioid antagonist that is very similar to naltrexone. It was recently approved in the US and Europe for the treatment of Alcohol Use Disorders. Like naltrexone, it can be used with The Sinclair Method, or as-needed, or (more generally prescribed) taken once daily with a goal of abstinence. 

The differences between naltrexone and nalmefene include "no dose-dependent association with toxic effects to the liver, greater oral bioavailability, longer duration of antagonist action, and more competitive binding with opioid receptor subtypes that are thought to reinforce drinking."1 

There are not a lot of significant studies about nalmefene, however it is being heavily marketed by the pharmaceutical company that owns the patent. 

 

1. Sinclair JD. Method for treating alcoholism with nalmefene - Patent. United States Pat Database. 1992: 1-7.

Burlison, Linda (2016-02-02). A Prescription for Alcoholics - Medications for Alcoholism (Kindle Locations 7550-8021). Stonecutter Books. Kindle Edition. 

 

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