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Nicholas

'Titrate' and 'Switch'

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Nicholas

Hi I am Nick I am new here and an alcoholic.  I discussed thsi with my doctor (in France) and he has referred me to a specialistw ith the aim of prescribing me baclafen.  I just found and joined this site today.  Looking at a couple of threads I saw two key words: 'switch' and 'titrate'.  Can someone explain these please. 

Many thanks in advance

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Mom2JTx3

@Nicholas  Welcome to the forum!  If you're French, check out Baclofene.com. There is a ton of great information there as well. 

Titrating is how you slowly increase your dose of Baclofen until you reach indifference to alcohol.  This indifference is also referred to as the switch.

See here for the guide:  http://www.theendofmyaddiction.org/forum/102-prescribing-guide-for-baclofen-in-the-treatment-of-alcoholism-for-physicians/

You will have so much more support in France than we have here in the US.  Good luck!

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Ne1

Hi, Nicholas and a belated welcome to the forum. 

I would add to mom's explanation that some people experience a dramatic off-switch to their desire for alcohol when they reach 'indifference'. Indifference is when we are literally indifferent to alcohol. When I was indifferent I couldn't have cared less about drinking booze. Not only did I not crave it, it simply didn't appeal. I didn't really experience the off-switch, but a gradual decline in my drinking until one day I decided not to drink at all and found that it didn't bother me. It was pretty unbelievable, as previous to that, I'd never experienced anything like it. 

Hope you can get the help you need and find the success I did! 

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empyr3al

WELCOME!

Bac mixed wierd with my meds (campral, naltrexone, mirtazapine).   I'm saving up enough Bac for when my benefits run out so I can try titrating up again.  I had a weird experience with BAC because I pushed it way to fast.  There are some handy charts but watch yourself or have someone watch how your behaviour changes.  Those drugs I mentioned are very expensive so BAC is gonna be my have to go to.  Mirt is cheap too if you are depressed, its helpful but it will make you sleep for crazy periods of time.

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Nicholas

Hi  a follow up on my post from almost three months.  initially my doctor was relucnat to prescribe me Baclofen and wanted to start me on Selincr wich she said was easier to manage and had been developed specifically for alcohol addiction.  Six weeks of tht produced no real results (other than a small drop which i suspect was due to being obliged to keep a diary of consumption, triggers and time satrted drinking). So she then started me on something else Alolo or something i forget which made things worse as it made me so stupid that I needed alcohol to do daily tasks.  I ditched that after two weeks and have now been on Baclafon for almost three weeks.  My alohol conusmption has lamost halved, particularly in the last four days, since I have been on 5 baclofan a day.   I can easily see the day when i get through a day without using my crotch.  Only problesm are I am offten incrediby sleepy, have becme quite withdrawn (inrospection is not a bad thing sometimes), sometimes wonder if I am safe to drive and have lost much appetite - which as a skinny guy could be a problem.  

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empyr3al

@Nicholas Mirtazapine has shown high effectiveness for getting life back in order and nearly AF.  Something to think about but yes it makes you sleepy and I require a tea in the morning to get going.  I also noted it worked great in the mornings because you take it at night that by mid afternoon I was craving again and the effect had worn off.  Now because this makes your sleepy unless you can afford a nap he has me using a pill cutter to split doses so there is an after 5 quarter to balance it all out.  Just my experience with a drug you haven't tried.  As you describe you are a skinny guy.  Mirtazapine brings back appetite and made me gain 10 lbs which is a good thing and put my BMI back at its right spot.  Just something to ask about.  Its cheap and out of patent.  Its known as Remeron by trademark.

The other two you mention I have never heard of and will have to check scihub or some other resources to see what you mean and the studies done.  I think you mean Silincro and I'm unsure of the other your mentioned.  I tried altering what you named it a couple ways and couldn't get a hit on it.  Let me know what it was called.

Thanks for following up.  I did notice the withdrawn effect of baclofen too.

Edited by empyr3al
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Molly78

Selincro is nalmefene in the UK which most people have found pretty useless.  It has been "developed specifically for alcohol addiction" by greedy Big Pharma who can't any longer make megabucks from naltrexone (which nalmefene is chemically similar to) because it is now available as a generic. 

Not sure what the second drug was, but sounds like you are doing really well on baclofen so why not stick with it?  Sedation can be a problem at the beginning but if you stay at the dose you are on (which seems to be working well) most people find it becomes less of a problem over time.

Keep us posted!

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Nicholas
12 hours ago, Molly78 said:

Not sure what the second drug was, but sounds like you are doing really well on baclofen so why not stick with it?  Sedation can be a problem at the beginning but if you stay at the dose you are on (which seems to be working well) most people find it becomes less of a problem over time.

Molly  I am on a combination of Selincro and Baclofan.  Will discuss withd octor next week if the Selincro is still necessary 9and will check out the name of the other one - I'm not saying it's no good just it didn't workfor me).  Thank for the info and support! 

 

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Nicholas
12 hours ago, empyr3al said:

@Nicholas Hi Empyr3al. What is AF?  And is Mirtazapine aprescription drug or available over the counter?  I guess that might depend where you are..

 

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empyr3al

AF is an abbreviation for Alcohol Free.  There is a FAQ on either here or Mywayout that explains these terms.  AWS, SE's, etc.  Mirtazapine in this country is by prescription and easy to get.  I'm sure it depends where you are but as its technically classed as an antidepressant in Canada so its prescription here.  Its been cross examined for AF (Alcohol Free) and in a relatively small group, something like 10 people (the total), 75% changed their lives and were functioning and had jobs where as they did not before, in only a couple weeks.  I can find the link.  Comorbid Alcohol and Depression.  There are more documents I can find about it.  By comparison to a lot of patented drugs its cheap.  So including the pharmacist charge its less than 20$ CAD (15$ USD) a month so insanely cheap by comparison to some of the other drugs.  On another forum I posted a list of over 15 legal drugs I have tested ranging all the way as high as $270/month.  What I did at max was like $1000 a month, and am now at about $500/mo.  I have tried a variety of things and what they did over the last decade.  On MYO (mywayout) there is a list of legal and some illegal drugs I have tried.  I have the same nickname if you want to look it up under "Just Starting Out" and "Never introduced myself correctly" is the thread and close to the top.  I don't want to hijack your thread so take a look if you want.  Its visible I think even if you are not a member.

Just in case you are curious.  There is no wonder drug and everyone is different.  My theory is that just because its new and its patented does not make it better.

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Molly78
4 hours ago, empyr3al said:

 My theory is that just because its new and its patented does not make it better.

Too damn right, @empyr3al!  

Just noticed Nicholas is in France so cost of drugs & medical treatment probably different there from Canada & UK.  More importantly France is the capital of baclofen research & prescribing, so amazed his doc bothered with Selincro.  @Nicholasas long as your medication is free I would stay on both, but I wouldn't keep paying for Selincro.  The link to the French website for baclofen is somewhere on this site & it's supposed to be a good website & in French as well.  Not that you seem to need that, your English is very good.

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empyr3al

@NicholasThis is a simple short list of what lingo we use around here.  There is way more to it and we often use way more than this list but its contextual and often understood while you reply to someone what you mean when you short cut like AF or AWS or NAL.

There are dozens, like Camp (Campral), Mirt (Mirazapine/Remeron).  Countless more buf AF means Alcohol Free.  Not sure what we use for Alcohol Reduced or Controlled yet; but it comes out in conversation.  Welcome and best of luck.

Edited by empyr3al

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Nicholas
1 hour ago, Molly78 said:

Too damn right, @empyr3al!  

  More importantly France is the capital of baclofen research & prescribing, so amazed his doc bothered with Selincro.

 

It was a French docor who expermeneted with Baclofan to treat his onw alcoholism  i i rememebr rightly:  The Seventh glass?  I can't remeber his name though.   @Nicholasthis site & it's supposed to be a good website & in French as well.  Not that you seem to need that, your English is very good.

That's because i am a native English speaker:-)

 

1 hour ago, Molly78 said:

 

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Molly78

It was Olivier Ameisen who wrote about it in a book called originally "The end of my addiction".  He was a French doctor working in the USA.  This website is named after his book.  We are many of us indebted to him.

It's worth a read @Nicholas if you are taking baclofen.

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