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stillhoping

Baclofen dosage question

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stillhoping

Hi everybody!  Have a question about whem to take my baclofen.  I just started on it about a month ago and have been increasing my dosage by 5 mg every 5 days, but was splitting it up into taking it about every 3-4 hours.  i will be iincreasing it to 60 mg tomorrow - should I be taking 2 10mg pills 3 times a day or splitting the dosage throughout the day? Would appreciate any feedback

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Felina

Hi @stillhoping! If you're tolerating the baclofen pretty well so far, taking it three times a day is pretty standard. Since baclofen has a short half-life, you will want to space the doses out as evenly as possible, i.e. 6 a.m., 2 p.m, and 10 p.m. Some people divide the doses up further if they're suffering from strong side effects. Your titration schedule is conservative, which is a good thing. A lot of people are so desperate for relief that they go up in dosage too fast and then get slammed by the SEs (which often catch up with people several days after a hefty inrease). I'd say keep doing what you're doing, and stick with the slow, steady titration.

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stillhoping

Thanks very much for your help. Yes, my tolerance for baclofen has been good so will try the 3 times a dsy routine. I get the desperation thing to try and fix it right away but am willing to let the process take its course. Thx again for the knowledge

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falconwood

Hi from Holland (Europe 😉 & my apologies for my poor language skills.

My doctor from Paris, France (I don't feel comfortable publishing his name, sorry) is a famous psychiatrist, researcher and author of many publications. Was a personal friend of Olivier Ameisen (I visited the grave of my hero, in Paris last month). Here's what my doctor explained to me:

The only dose that counts is the last one you take. All others have the sole purpose of minimising side effects. This last dose, should be taken one hour before you typically start  craving for alcohol. Important: if you start craving at 17 each workday, but at 16 during weekends, you take 16:00 as the basis, meaning you want to have your latest dose at 15:00, every day.

Baclofen reaches max plasma level in about 60 minutes after oral intake. Half time is 4-6 hours. So if possible, put 4-5 hours in between two doses. So with your 'craving time', count backwards to spread the 3 doses accordingly. Set your alarms and stick to them. If I miss one and take 2 doses too close to each other, the Baclofen can hit me hard. So whenever I miss my alarm, I change my entire schedule for that day.

Titration is important. So is tapering to prevent Baclofen Withrawal Syndrome. Given 3 doses per day, you start with 0 0 10. After 3 days, 0 10 10 and next, 10 10 10. Increase towards 10 10 20, and so forth. If side effects get too nasty, revert back to your previous schema. If this doesn't help, reduce slowly. Wait a bit longer before you increase again.

I myself have very easy side effects (mood, sleep, tinnitus, unable to drive & work, apathy), so I went back from 100 to 60mg DD for more than a month. I use Friday's to increase my dose, Mondays to correct if necessary. Also, I have decided to go for 4 intake moments: 9, 13, 17, 22. Makes my nights wonderful (I now sleep 8 hrs non-stop where I did 4-6 for years). My drinking is about 1/5 of what it used to be; still my target is complete abstinence.

Honestly I can't tell how to dose when you are an all day drinker. My guess would be to have 4 intake moments across the entire day, with your most important dose being the one when you wake up.

Hope this helps you and others. I don't follow this forum, but you can reach me via email at fnwd222@yahoo.com.

 

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