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  1. Greg

    Lyrica (pregabalin)

    I posted about this medication in MWO but drew some criticism by people saying the drug was not suitable for alcoholics. It works via the same alpha(2)delta subunit of voltage-gated calcium channels in the brain as gabapentin, so should be appropriate in alcoholism if gabapentin is. It is about 6 times as potent as gabapentin (in milligrams) and reaches peak levels in about 1 and a half hours, versus 3 hours or so for gabapentin. The following is an article summarising evidence for its use in alcohol dependence: https://www.ncbi.nlm.nih.gov/pubmed/23132700
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