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[Disclaimer: I have some background in pharmacology, but I am not a medical doctor.] Hey everyone! What follows is information regarding the mechanism of action of baclofen as well as similar substances, their effect on anxiety, and my thoughts/implications. [I've decided to add elements of my personal story and current situation in the hopes that others can learn from my insights as well as my mistakes.] Baclofen's mechanism of action involves agonism of the GABAb receptor, as well as slight inhibition/attenuation of voltage-dependent calcium channels (VDCC). Some studies suggest th
DefinitelyMedicated posted a topic in General DiscussionsI'm on a lot of medication for my alcohol use disorder and major depression disorder /w concomitant anxiety. ALCOHOLISM: Acamprosate [Campral] 333mg TT (666mg) TID CF Baclofen [Lioresal] 20mg TID Topiramate [Topamax] 50mg BID DEPRESSION: Sertraline [Zoloft] 100mg TT (200mg) QD Aplenzin 348mg (bupropion [Wellbutrin] hbr) QAM Aripiprazole [Abilify] 20mg QD ANXIOLYSIS: Propranolol [Inderal] 60mg TID Amitriptyline [Elavil] 50mg QHS --- I stumbled upon a 750ml (fifth) of vodka I hid from myself three days ago; I am now thinking that drinking is gross! (after I e
Hi All, I just found this forum today and have read some great stuff. I have always been a drinker- most of it of the binging variety. In the past I used to drink 2-4 nights per week fairly heavily. However in the last (6) months I've cut back to just two nights per week (Friday and Saturday). On these nights I typically drink between 8-10 light beers. Just as any FYI, I have tried AA in the past and it just wasn't for me. I didn't feel like I belonged. I've never been arrested or had any trouble from drinking. I also felt like the people at AA wanted me t