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Hey guys, I'm having a very hard time tapering down gabapentin (currently at 1200mg/day) while on high dose baclofen (140mg/day). Prior to my use of baclofen, I had been able to taper off of gabapentin with relatively little discomfort - some anxiety and insomnia for a few days after stopping, but it was manageable. This time around, however, I'm getting a large increase in anxiety every time that I try to reduce my dose for a stretch. Has anyone else had any success in tapering off of gabapentin while taking baclofen?
[Disclaimer: I have some background in pharmacology, but I am not a medical doctor.] Hey everyone! What follows is information regarding the mechanism of action of baclofen as well as similar substances, their effect on anxiety, and my thoughts/implications. [I've decided to add elements of my personal story and current situation in the hopes that others can learn from my insights as well as my mistakes.] Baclofen's mechanism of action involves agonism of the GABAb receptor, as well as slight inhibition/attenuation of voltage-dependent calcium channels (VDCC). Some studies suggest th